Cell Protein and Malignancy Bakersfield CA

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells in Bakersfield.

James Ying-Cheng Chang, MD
(661) 316-8888
3550 Q St Ste 205
Bakersfield, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Taipei Med Coll, Taipei, Taiwan (385-04 Prior 1/71)
Graduation Year: 1979

Data Provided by:
Daniel Peter Silver, MD
2808 F St
Bakersfield, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Univ Of Ca, San Francisco, Sch Of Med, San Francisco Ca 94143
Graduation Year: 1994

Data Provided by:
Dean Leroy Davis
(661) 632-5700
2215 Truxtun Ave
Bakersfield, CA
Specialty
Radiation Oncology

Data Provided by:
James L Harpstreith, MD
3550 Q St Ste 106
Bakersfield, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Northwestern Univ Med Sch, Chicago Il 60611
Graduation Year: 1963

Data Provided by:
Kim Ng
(661) 322-2206
6501 Truxtun Ave
Bakersfield, CA
Specialty
Internal Medicine, Medical Oncology

Data Provided by:
Kyaw K Tu, MD
(661) 635-3460
3733 San Dimas St
Bakersfield, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
Dean Leroy Davis, MD
(661) 632-5700
2215 Truxtun Ave
Bakersfield, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Northwestern Univ Med Sch, Chicago Il 60611
Graduation Year: 1985

Data Provided by:
Kyaw K Tun
(800) 353-5400
3733 San Dimas St
Bakersfield, CA
Specialty
Hematology / Oncology

Data Provided by:
John Eric P Byfield, MD
(805) 327-2100
3550 Q St Ste 106
Bakersfield, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Univ Of Ca, Los Angeles, Ucla Sch Of Med, Los Angeles Ca 90024
Graduation Year: 1965
Hospital
Hospital: Bakersfield Mem Hosp, Bakersfield, Ca; Kern Med Ctr, Bakersfield, Ca
Group Practice: Radiation Therapy Assoc

Data Provided by:
Alan D Cartmell, MD
(661) 322-2206
6501 Truxtun Ave
Bakersfield, CA
Specialties
Oncology (Cancer), Hematology-Internal Medicine
Gender
Male
Languages
Spanish
Education
Medical School: In Univ Sch Of Med, Indianapolis In 46202
Graduation Year: 1983
Hospital
Hospital: Mercy Hosp -Bakersfield, Bakersfield, Ca
Group Practice: Comprehensive Blood & Cancer

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Cell Protein and Malignancy

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A protein called STAT3 plays a major role in the change of normal cells into cancerous cells, according to U.S. researchers, who say the finding could lead to new cancer treatments.

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells, said the study's leader, David E. Levy, a professor of pathology and microbiology at New York University's Langone Medical Center.

Mitochondria -- the energy source in cells -- are known to be critical to tumor cell metabolism.

"These results open the possibility that inhibiting the mitochondrial function of STAT3 could be a promising cancer therapy in the future," Levy said in a news release from the university's medical school.

"By knowing this mitochondrial function is critical, it may be possible to design therapeutic strategies that specifically target this function while sparing the other functions of the protein, such as its ability to turn genes on," he explained. "Therefore, we would hope that inhibitors could be developed that would be highly specific for cancer cells."

Levy and his team made the discovery about the mitochondrial role of STAT3 by analyzing tumors caused by the Ras oncogene, which has been determined to be involved in many human cancers.

A report on the findings appears in the June 26 issue of Science.

"Future experiments will need to determine if a similar mitochondrial role for STAT3 is critical for other types of cancer as well," Levy said. "We'll also need a better understanding of the biochemical basis for the function of STAT3. For instance, we are trying to find out what STAT3 does in mitochondria, what enzymes and processes it regulates and how these processes differ in tumors compared to normal cells."

More information

The U.S. National Cancer Institute has more about cancer.

SOURCE: NYU School of Medicine, news release, June 25, 2009

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