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Cell Protein and Malignancy Fresno CA

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells in Fresno.

Lisa E Lamberth
(559) 228-5330
2615 E Clinton Ave
Fresno, CA
Specialty
Hematology / Oncology

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Ming Choo Kuan, MD
(559) 459-4000
2615 E Clinton Ave
Fresno, CA
Specialties
Oncology (Cancer)
Gender
Female
Education
Medical School: Nat'L Univ Of Singapore, Fac Of Med, Singapore
Graduation Year: 1985

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Anita Maria Xavier
(559) 228-5327
2615 E Clinton Ave
Fresno, CA
Specialty
Hematology / Oncology

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Lawrence Mark Stolberg, MD
(559) 459-4000
445 S Cedar Ave
Fresno, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Wayne State Univ Sch Of Med, Detroit Mi 48201
Graduation Year: 1968

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Abdul Mustajeeb Haseeb, MD
6121 N Thesta St
Fresno, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Dow Med Coll, Univ Of Karachi, Karachi, Pakistan
Graduation Year: 1990

Data Provided by:
Anita Maria Xavier, MD
(559) 225-6100
2615 E Clinton Ave
Fresno, CA
Specialties
Oncology (Cancer)
Gender
Female
Education
Medical School: Univ Of Chicago, Pritzker Sch Of Med, Chicago Il 60637
Graduation Year: 1976

Data Provided by:
Ming C Kua, MD
(559) 225-6100
2615 E Clinton Ave
Fresno, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
Venkateswara Reddy Avula
(559) 459-5721
445 S Cedar Ave
Fresno, CA
Specialty
Internal Medicine, Hematology / Oncology

Data Provided by:
Dina Ibrahim, MD
(559) 438-7530
6121 N Thesta St Ste 204
Fresno, CA
Specialties
Oncology (Cancer)
Gender
Female
Education
Medical School: Univ Of Damascus, Fac Of Med, Damascus, Syria
Graduation Year: 1990

Data Provided by:
Christopher R Perkins, MD
(559) 438-7390
6121 N Thesta St Ste 204
Fresno, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Univ La Salle, Esc Mexicana De Med, Mexico Df, Mexico
Graduation Year: 1983

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Cell Protein and Malignancy

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A protein called STAT3 plays a major role in the change of normal cells into cancerous cells, according to U.S. researchers, who say the finding could lead to new cancer treatments.

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells, said the study's leader, David E. Levy, a professor of pathology and microbiology at New York University's Langone Medical Center.

Mitochondria -- the energy source in cells -- are known to be critical to tumor cell metabolism.

"These results open the possibility that inhibiting the mitochondrial function of STAT3 could be a promising cancer therapy in the future," Levy said in a news release from the university's medical school.

"By knowing this mitochondrial function is critical, it may be possible to design therapeutic strategies that specifically target this function while sparing the other functions of the protein, such as its ability to turn genes on," he explained. "Therefore, we would hope that inhibitors could be developed that would be highly specific for cancer cells."

Levy and his team made the discovery about the mitochondrial role of STAT3 by analyzing tumors caused by the Ras oncogene, which has been determined to be involved in many human cancers.

A report on the findings appears in the June 26 issue of Science.

"Future experiments will need to determine if a similar mitochondrial role for STAT3 is critical for other types of cancer as well," Levy said. "We'll also need a better understanding of the biochemical basis for the function of STAT3. For instance, we are trying to find out what STAT3 does in mitochondria, what enzymes and processes it regulates and how these processes differ in tumors compared to normal cells."

More information

The U.S. National Cancer Institute has more about cancer.

SOURCE: NYU School of Medicine, news release, June 25, 2009

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