Cell Protein and Malignancy Modesto CA

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells in Modesto.

Jay Jiunn-Jer Chen, MD
(209) 575-3839
1541 Florida Ave Ste 101
Modesto, CA
Specialties
Oncology (Cancer), Hematology-Internal Medicine
Gender
Male
Languages
Chinese
Education
Medical School: Taipei Med Coll, Taipei, Taiwan (385-04 Prior 1/71)
Graduation Year: 1977
Hospital
Hospital: Doctors Med Ctr, Modesto, Ca; Memorial Hosp Med Ctr, Modesto, Ca
Group Practice: California Neurological Ctr

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Mussa Banisadre, MD
(209) 524-7000
1524 McHenry Ave Ste 120
Modesto, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Shiraz Univ Of Med Sci, Shiraz, Iran
Graduation Year: 1973

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Jedd Mercer Monson, MD
1316 Nelson Ave
Modesto, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Stanford Univ Sch Of Med, Stanford Ca 94305
Graduation Year: 1991

Data Provided by:
Amarjit Singh Dhaliwal
(209) 529-2000
1401 Spanos Ct
Modesto, CA
Specialty
Hematology / Oncology

Data Provided by:
Christopher R Neville, MD
(209) 572-7237
1700 Coffee Rd
Modesto, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Univ Of Az Coll Of Med, Tucson Az 85724
Graduation Year: 1991

Data Provided by:
Abdol Abbas Mojab
(209) 524-7000
1325 Melrose Ave
Modesto, CA
Specialty
Hematology / Oncology

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William C Johnson
(209) 575-5870
1316 Nelson Ave
Modesto, CA
Specialty
Radiation Oncology

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Robert Lee Levy
(209) 529-2000
1401 Spanos Ct
Modesto, CA
Specialty
Hematology / Oncology

Data Provided by:
David Alan Shiba, MD
(209) 524-1211
600 Coffee Rd
Modesto, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Univ Of Ct Sch Of Med, Farmington Ct 06032
Graduation Year: 1986

Data Provided by:
Manouchehr Azad, MD
(209) 572-7237
1700 Coffee Rd
Modesto, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Teheran Univ, Fac Of Med, Teheran, Iran
Graduation Year: 1951

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Cell Protein and Malignancy

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A protein called STAT3 plays a major role in the change of normal cells into cancerous cells, according to U.S. researchers, who say the finding could lead to new cancer treatments.

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells, said the study's leader, David E. Levy, a professor of pathology and microbiology at New York University's Langone Medical Center.

Mitochondria -- the energy source in cells -- are known to be critical to tumor cell metabolism.

"These results open the possibility that inhibiting the mitochondrial function of STAT3 could be a promising cancer therapy in the future," Levy said in a news release from the university's medical school.

"By knowing this mitochondrial function is critical, it may be possible to design therapeutic strategies that specifically target this function while sparing the other functions of the protein, such as its ability to turn genes on," he explained. "Therefore, we would hope that inhibitors could be developed that would be highly specific for cancer cells."

Levy and his team made the discovery about the mitochondrial role of STAT3 by analyzing tumors caused by the Ras oncogene, which has been determined to be involved in many human cancers.

A report on the findings appears in the June 26 issue of Science.

"Future experiments will need to determine if a similar mitochondrial role for STAT3 is critical for other types of cancer as well," Levy said. "We'll also need a better understanding of the biochemical basis for the function of STAT3. For instance, we are trying to find out what STAT3 does in mitochondria, what enzymes and processes it regulates and how these processes differ in tumors compared to normal cells."

More information

The U.S. National Cancer Institute has more about cancer.

SOURCE: NYU School of Medicine, news release, June 25, 2009

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