Cell Protein and Malignancy Redding CA

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells in Redding.

Mahesh C Pant
(530) 245-5900
963 Butte St
Redding, CA
Specialty
Radiation Oncology

Data Provided by:
Jed Loren Freeman, MD
(530) 242-8822
2510 Airpark Dr Ste 103
Redding, CA
Specialties
Oncology (Cancer), Hematology-Internal Medicine
Gender
Male
Languages
Spanish
Education
Medical School: Univ Of Nv Sch Of Med, Reno Nv 89557
Graduation Year: 1986
Hospital
Hospital: Redding Med Ctr, Redding, Ca; Mercy Med Ctr -Redding, Redding, Ca
Group Practice: North State Cancer Speciality

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Sharon Pereira-Matsumoto
(530) 225-7450
2175 Rosaline Ave
Redding, CA
Specialty
Radiation Oncology

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Michael Louis Figueroa, MD
(530) 244-2223
2175 Rosaline Ave
Redding, CA
Specialties
Oncology (Cancer), Hematology-Internal Medicine
Gender
Male
Languages
Spanish
Education
Medical School: Univ Of Nv Sch Of Med, Reno Nv 89557
Graduation Year: 1986
Hospital
Hospital: Redding Med Ctr, Redding, Ca; Mercy Med Ctr -Redding, Redding, Ca
Group Practice: Cancer Care Consultants-N CA

Data Provided by:
Rodney Raymond Rodriguez
(530) 245-5900
963 Butte St
Redding, CA
Specialty
Radiation Oncology

Data Provided by:
Sharon Pereiramatsumoto, MD
(530) 225-7450
2175 Rosaline Ave
Redding, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Female
Education
Medical School: Med Coll Of Wi, Milwaukee Wi 53226
Graduation Year: 1987

Data Provided by:
Ajay Kumar Verma, MD
(530) 244-7400
1555 East St Ste 230
Redding, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Univ Coll Of Med Scis, Univ Of Delhi, New Delhi, Delhi, India
Graduation Year: 1979

Data Provided by:
Sander B Saidman
(530) 243-1236
2020 Court St
Redding, CA
Specialty
Radiation Oncology

Data Provided by:
Richard Wilbur Lehfeldt, MD
(530) 225-7450
Redding, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Or Hlth Sci Univ Sch Of Med, Portland Or 97201
Graduation Year: 1967

Data Provided by:
Chalmer Gregg Carter, MD
(530) 244-2223
2175 Rosaline Ave
Redding, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Univ Of Ok Coll Of Med, Oklahoma City Ok 73190
Graduation Year: 1991

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Cell Protein and Malignancy

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A protein called STAT3 plays a major role in the change of normal cells into cancerous cells, according to U.S. researchers, who say the finding could lead to new cancer treatments.

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells, said the study's leader, David E. Levy, a professor of pathology and microbiology at New York University's Langone Medical Center.

Mitochondria -- the energy source in cells -- are known to be critical to tumor cell metabolism.

"These results open the possibility that inhibiting the mitochondrial function of STAT3 could be a promising cancer therapy in the future," Levy said in a news release from the university's medical school.

"By knowing this mitochondrial function is critical, it may be possible to design therapeutic strategies that specifically target this function while sparing the other functions of the protein, such as its ability to turn genes on," he explained. "Therefore, we would hope that inhibitors could be developed that would be highly specific for cancer cells."

Levy and his team made the discovery about the mitochondrial role of STAT3 by analyzing tumors caused by the Ras oncogene, which has been determined to be involved in many human cancers.

A report on the findings appears in the June 26 issue of Science.

"Future experiments will need to determine if a similar mitochondrial role for STAT3 is critical for other types of cancer as well," Levy said. "We'll also need a better understanding of the biochemical basis for the function of STAT3. For instance, we are trying to find out what STAT3 does in mitochondria, what enzymes and processes it regulates and how these processes differ in tumors compared to normal cells."

More information

The U.S. National Cancer Institute has more about cancer.

SOURCE: NYU School of Medicine, news release, June 25, 2009

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