Cell Protein and Malignancy Sacramento CA

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells in Sacramento.

Delphine W Ong
(916) 454-6700
2800 L St
Sacramento, CA
Specialty
Internal Medicine, Medical Oncology

Data Provided by:
Vincent Caggiano, MD
(916) 454-6500
2800 L St Ste 420
Sacramento, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Univ Di Bologna, Fac Di Med E Chirurgia, Bologna, Italy
Graduation Year: 1960

Data Provided by:
Nitin Rohatgi, MD
(916) 454-6700
2800 L St Ste 300
Sacramento, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: All India Inst Of Med Sci, Ansari Nagar, New Delhi, Delhi, India
Graduation Year: 1990

Data Provided by:
John Joseph Fisher, MD
(916) 454-6700
2800 L St Ste 300
Sacramento, CA
Specialties
Oncology (Cancer), Hematology-Internal Medicine
Gender
Male
Education
Medical School: Univ Di Bologna, Fac Di Med E Chirurgia, Bologna, Italy
Graduation Year: 1963

Data Provided by:
Albert Brandt Schraner
(916) 453-9999
3161 L St
Sacramento, CA
Specialty
Radiology, Nuclear Medicine, Radiation Oncology, Neuroradiology

Data Provided by:
Vincent Caggian, MR
(916) 454-6500
2800 L St Ste 420
Sacramento, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
Harvey Brian Wolkov
(916) 454-6600
2800 L St
Sacramento, CA
Specialty
Radiation Oncology

Data Provided by:
Anthony Tswenty Pu, MD
(916) 454-6600
2800 L St Ste 10
Sacramento, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Washington Univ Sch Of Med, St Louis Mo 63110
Graduation Year: 1990

Data Provided by:
Lisa M Guirguis
(916) 453-5951
1020 29th St
Sacramento, CA
Specialty
Surgical Oncology

Data Provided by:
Vincent Chung, MD
(916) 454-6516
2800 L St Ste 420
Sacramento, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Univ Of Tn, Memphis, Coll Of Med, Memphis Tn 38163
Graduation Year: 1998
Hospital
Hospital: City Of Hope National Med Ctr, Duarte, Ca
Group Practice: Chinatown Christian Medical

Data Provided by:
Data Provided by:

Cell Protein and Malignancy

Provided By:

A protein called STAT3 plays a major role in the change of normal cells into cancerous cells, according to U.S. researchers, who say the finding could lead to new cancer treatments.

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells, said the study's leader, David E. Levy, a professor of pathology and microbiology at New York University's Langone Medical Center.

Mitochondria -- the energy source in cells -- are known to be critical to tumor cell metabolism.

"These results open the possibility that inhibiting the mitochondrial function of STAT3 could be a promising cancer therapy in the future," Levy said in a news release from the university's medical school.

"By knowing this mitochondrial function is critical, it may be possible to design therapeutic strategies that specifically target this function while sparing the other functions of the protein, such as its ability to turn genes on," he explained. "Therefore, we would hope that inhibitors could be developed that would be highly specific for cancer cells."

Levy and his team made the discovery about the mitochondrial role of STAT3 by analyzing tumors caused by the Ras oncogene, which has been determined to be involved in many human cancers.

A report on the findings appears in the June 26 issue of Science.

"Future experiments will need to determine if a similar mitochondrial role for STAT3 is critical for other types of cancer as well," Levy said. "We'll also need a better understanding of the biochemical basis for the function of STAT3. For instance, we are trying to find out what STAT3 does in mitochondria, what enzymes and processes it regulates and how these processes differ in tumors compared to normal cells."

More information

The U.S. National Cancer Institute has more about cancer.

SOURCE: NYU School of Medicine, news release, June 25, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com