Cell Protein and Malignancy Sacramento CA

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells in Sacramento.

Samer Shihabi, MD
(916) 454-6700
2800 L St Ste 300
Sacramento, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Univ Of Damascus, Fac Of Med, Damascus, Syria
Graduation Year: 1991

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Luko Michael Laptalo
(916) 454-6700
2800 L St
Sacramento, CA
Specialty
Hematology

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Gregory Murray Graves, MD
(916) 454-6900
2800 L St
Sacramento, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Rush Med Coll Of Rush Univ, Chicago Il 60612
Graduation Year: 1974

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Harvey Brian Wolkov
(916) 454-6600
2800 L St
Sacramento, CA
Specialty
Radiation Oncology

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David Thurston Harrison, MD
(916) 454-6700
2800 L St Ste 300
Sacramento, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Johns Hopkins Univ Sch Of Med, Baltimore Md 21205
Graduation Year: 1970

Data Provided by:
Vincent Chung, MD
(916) 454-6516
2800 L St Ste 420
Sacramento, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Univ Of Tn, Memphis, Coll Of Med, Memphis Tn 38163
Graduation Year: 1998
Hospital
Hospital: City Of Hope National Med Ctr, Duarte, Ca
Group Practice: Chinatown Christian Medical

Data Provided by:
Delphine W Ong
(916) 454-6700
2800 L St
Sacramento, CA
Specialty
Internal Medicine, Medical Oncology

Data Provided by:
Samer Shihabi
(916) 454-6700
2800 L St
Sacramento, CA
Specialty
Hematology

Data Provided by:
Jay Colin Owens, MD
(916) 454-6868
2800 L St
Sacramento, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Univ Of Ca, Los Angeles, Ucla Sch Of Med, Los Angeles Ca 90024
Graduation Year: 1974

Data Provided by:
Anthony Tswenty Pu, MD
(916) 454-6600
2800 L St Ste 10
Sacramento, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Washington Univ Sch Of Med, St Louis Mo 63110
Graduation Year: 1990

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Cell Protein and Malignancy

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A protein called STAT3 plays a major role in the change of normal cells into cancerous cells, according to U.S. researchers, who say the finding could lead to new cancer treatments.

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells, said the study's leader, David E. Levy, a professor of pathology and microbiology at New York University's Langone Medical Center.

Mitochondria -- the energy source in cells -- are known to be critical to tumor cell metabolism.

"These results open the possibility that inhibiting the mitochondrial function of STAT3 could be a promising cancer therapy in the future," Levy said in a news release from the university's medical school.

"By knowing this mitochondrial function is critical, it may be possible to design therapeutic strategies that specifically target this function while sparing the other functions of the protein, such as its ability to turn genes on," he explained. "Therefore, we would hope that inhibitors could be developed that would be highly specific for cancer cells."

Levy and his team made the discovery about the mitochondrial role of STAT3 by analyzing tumors caused by the Ras oncogene, which has been determined to be involved in many human cancers.

A report on the findings appears in the June 26 issue of Science.

"Future experiments will need to determine if a similar mitochondrial role for STAT3 is critical for other types of cancer as well," Levy said. "We'll also need a better understanding of the biochemical basis for the function of STAT3. For instance, we are trying to find out what STAT3 does in mitochondria, what enzymes and processes it regulates and how these processes differ in tumors compared to normal cells."

More information

The U.S. National Cancer Institute has more about cancer.

SOURCE: NYU School of Medicine, news release, June 25, 2009

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