Cell Protein and Malignancy Stockton CA

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells in Stockton.

Imtiaz Akram Malik, MD
(209) 941-0791
2800 N California St Ste 7
Stockton, CA
Specialties
Internal Medicine, Medical Oncology
Gender
Male
Education
Medical School: King Edward Med Coll, Univ Of Punjab, Lahore, Pakistan
Graduation Year: 1977

Data Provided by:
Lynette Carter Hart, MD
(209) 467-6560
1800 N California St
Stockton, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Female
Education
Medical School: Univ Of Ca, San Francisco, Sch Of Med, San Francisco Ca 94143
Graduation Year: 1973

Data Provided by:
Prabhjit Singh Purewal, MD
(209) 477-2000
4722 Quail Lakes Dr Ste A
Stockton, CA
Specialties
Internal Medicine, Hematology-Oncology
Gender
Male
Education
Medical School: Armed Forces Med Coll, Univ Of Pune, Pune, Maharashtra, India
Graduation Year: 1983

Data Provided by:
Barry Tepperman, MD
(209) 575-5870
4722 Quail Lakes Dr
Stockton, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Univ Of Toronto, Fac Of Med, Toronto, Ont, Canada
Graduation Year: 1975

Data Provided by:
Abbas Taherali Ghadialy, MD
(209) 476-2000
1305 Tommydon St
Stockton, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: L T M Med Coll, Univ Of Bombay, Bombay, Maharashtra, India
Graduation Year: 1982

Data Provided by:
Aminder Singh Mehdi, MD
(209) 466-2626
2626 N California St # 201
Stockton, CA
Specialties
Oncology (Cancer), Hematology-Internal Medicine
Gender
Male
Education
Medical School: Dayanand Med Coll, Punjab Univ, Ludhiana, Punjab, India
Graduation Year: 1977
Hospital
Hospital: St Josephs Med Ctr, Stockton, Ca
Group Practice: Stockton Hematology

Data Provided by:
Prasad Dighe, MD
(209) 466-2626
2626 N California St
Stockton, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Med Coll, Baroda Univ, Baroda, Gujarat, India
Graduation Year: 1971

Data Provided by:
Vitune Vongtama
(209) 472-1848
4722 Quail Lakes Dr
Stockton, CA
Specialty
Radiation Oncology

Data Provided by:
James C Shum
(209) 476-2000
7373 West Ln
Stockton, CA
Specialty
Hematology / Oncology

Data Provided by:
Lay Lin Owyong
(209) 476-2000
7373 West Ln
Stockton, CA
Specialty
Hematology / Oncology

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Cell Protein and Malignancy

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A protein called STAT3 plays a major role in the change of normal cells into cancerous cells, according to U.S. researchers, who say the finding could lead to new cancer treatments.

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells, said the study's leader, David E. Levy, a professor of pathology and microbiology at New York University's Langone Medical Center.

Mitochondria -- the energy source in cells -- are known to be critical to tumor cell metabolism.

"These results open the possibility that inhibiting the mitochondrial function of STAT3 could be a promising cancer therapy in the future," Levy said in a news release from the university's medical school.

"By knowing this mitochondrial function is critical, it may be possible to design therapeutic strategies that specifically target this function while sparing the other functions of the protein, such as its ability to turn genes on," he explained. "Therefore, we would hope that inhibitors could be developed that would be highly specific for cancer cells."

Levy and his team made the discovery about the mitochondrial role of STAT3 by analyzing tumors caused by the Ras oncogene, which has been determined to be involved in many human cancers.

A report on the findings appears in the June 26 issue of Science.

"Future experiments will need to determine if a similar mitochondrial role for STAT3 is critical for other types of cancer as well," Levy said. "We'll also need a better understanding of the biochemical basis for the function of STAT3. For instance, we are trying to find out what STAT3 does in mitochondria, what enzymes and processes it regulates and how these processes differ in tumors compared to normal cells."

More information

The U.S. National Cancer Institute has more about cancer.

SOURCE: NYU School of Medicine, news release, June 25, 2009

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