Cell Protein and Malignancy Visalia CA

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells in Visalia.

Veena H Ramsinghani
(559) 624-3100
4945 W Cypress Avenue
Visalia, CA
Specialty
Radiation Oncology

Data Provided by:
Veena Haresh Ramsinghani, MD
(559) 449-5500
248 S Floral St
Visalia, CA
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Female
Education
Medical School: Grant Med Coll, Univ Of Bombay, Bombay, Maharashtra, India
Graduation Year: 1976

Data Provided by:
David Russell Bryson, MD
(559) 738-7577
5400 W Hillsdale Ave
Visalia, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Loma Linda Univ Sch Of Med, Loma Linda Ca 92350
Graduation Year: 1980

Data Provided by:
Shu Dean Hsu, MD
(559) 624-3000
4945 W Cypress Ave Ste C
Visalia, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Taipei Med Coll, Taipei, Taiwan (385-04 Prior 1/71)
Graduation Year: 1968

Data Provided by:
David Gallardo
(559) 686-1718
1018 N Cherry St
Tulare, CA
Specialty
Radiation Oncology

Data Provided by:
Youssef A Hanalla
(559) 624-3100
4945 W Cypress Avenue
Visalia, CA
Specialty
Radiation Oncology

Data Provided by:
Veena H Ramsinghan, MS
2902 S Jacob St
Visalia, CA
Specialties
Oncology (Cancer)
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
Rebecca Plourd Zulim, MD
(559) 636-3400
501 S Watson St
Visalia, CA
Gender
Female
Education
Medical School: Univ Of Ca, Los Angeles, Ucla Sch Of Med, Los Angeles Ca 90024
Graduation Year: 1988
Hospital
Hospital: Kaweah Delta District Hosp, Visalia, Ca

Data Provided by:
Ching Tseung Chiu
(559) 686-7048
1044 N Cherry St
Tulare, CA
Specialty
Hematology

Data Provided by:
Samuel S Kuo
(559) 688-8899
1088 N Cherry St
Tulare, CA
Specialty
Hematology / Oncology

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Cell Protein and Malignancy

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A protein called STAT3 plays a major role in the change of normal cells into cancerous cells, according to U.S. researchers, who say the finding could lead to new cancer treatments.

STAT3, which has a role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells, said the study's leader, David E. Levy, a professor of pathology and microbiology at New York University's Langone Medical Center.

Mitochondria -- the energy source in cells -- are known to be critical to tumor cell metabolism.

"These results open the possibility that inhibiting the mitochondrial function of STAT3 could be a promising cancer therapy in the future," Levy said in a news release from the university's medical school.

"By knowing this mitochondrial function is critical, it may be possible to design therapeutic strategies that specifically target this function while sparing the other functions of the protein, such as its ability to turn genes on," he explained. "Therefore, we would hope that inhibitors could be developed that would be highly specific for cancer cells."

Levy and his team made the discovery about the mitochondrial role of STAT3 by analyzing tumors caused by the Ras oncogene, which has been determined to be involved in many human cancers.

A report on the findings appears in the June 26 issue of Science.

"Future experiments will need to determine if a similar mitochondrial role for STAT3 is critical for other types of cancer as well," Levy said. "We'll also need a better understanding of the biochemical basis for the function of STAT3. For instance, we are trying to find out what STAT3 does in mitochondria, what enzymes and processes it regulates and how these processes differ in tumors compared to normal cells."

More information

The U.S. National Cancer Institute has more about cancer.

SOURCE: NYU School of Medicine, news release, June 25, 2009

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