Transplant for Metabolic Disorders Modesto CA

U.S. researchers are testing a new approach in cord-blood transplants to treat genetic metabolic disorders in babies while they're still in the womb. The new method uses a small, select number of therapeutic stem cells that have been treated to speed and improve engraftment (acceptance of the transplant by the body), explained Dr. Joanne Kurtzberg, a professor of pediatrics and pathology and director of the pediatric blood and marrow transplant program at Duke University Medical Center in Durham, N.C.

Richard Hugh Davis, MD
(209) 578-1582
1524 McHenry Ave Ste 540
Modesto, CA
Specialties
Pediatrics, Pediatric Allergy
Gender
Male
Education
Medical School: Univ Of Ca, San Francisco, Sch Of Med, San Francisco Ca 94143
Graduation Year: 1967

Data Provided by:
Wallace Banford Carroll, MD
(209) 524-1211
600 Coffee Rd
Modesto, CA
Specialties
Allergy & Immunology
Gender
Male
Education
Medical School: Univ Auto De Guadalajara, Fac De Med, Guadalajara, Jalisco, Mexico
Graduation Year: 1975

Data Provided by:
Wallace B Carroll
(209) 524-1211
600 Coffee Rd
Modesto, CA
Specialty
Allergy / Immunology

Data Provided by:
James T Jaing
(209) 557-1000
4601 Dale Rd
Modesto, CA
Specialty
Allergy / Immunology

Data Provided by:
William Thomas Poirier, MD
(209) 845-9957
250 S Oak Ave Ste B3
Oakdale, CA
Specialties
Otolaryngology, Allergy
Gender
Male
Education
Medical School: Hahnemann Univ Sch Of Med, Philadelphia Pa 19102
Graduation Year: 1971
Hospital
Hospital: Kings Daughters Med Ctr, Ashland, Ky

Data Provided by:
Marek Tadeusz Skowron, MD
(307) 548-5201
600 Coffee Rd
Modesto, CA
Specialties
Allergy & Immunology
Gender
Male
Education
Medical School: Akademia Med Im Karola Marcinkowskiego, Poznan, Poland
Graduation Year: 1985

Data Provided by:
Natalie Eileen Flod
(209) 524-1030
2030 Coffee Rd
Modesto, CA
Specialty
Allergy / Immunology

Data Provided by:
Natalie Eileen Flod, MD
(209) 524-1030
2030 Coffee Rd Ste C5
Modesto, CA
Specialties
Allergy & Immunology
Gender
Female
Education
Medical School: Univ Of Ca, Irvine, Ca Coll Of Med, Irvine Ca 92717
Graduation Year: 1972

Data Provided by:
James Tzehou Jaing, MD
(281) 580-6494
PO Box 350
Salida, CA
Specialties
Pediatrics, Allergy And Immunology
Gender
Male
Education
Medical School: In Univ Sch Of Med, Indianapolis In 46202
Graduation Year: 1995

Data Provided by:
Gregory William Bensch, MD
(209) 823-1092
200 Cottage Ave Ste 104
Manteca, CA
Specialties
Allergy & Immunology, Internal Medicine
Gender
Male
Education
Medical School: Univ Of Nc At Chapel Hill Sch Of Med, Chapel Hill Nc 27599
Graduation Year: 1994

Data Provided by:
Data Provided by:

Transplant for Metabolic Disorders

Provided By:

FRIDAY, Oct. 16 (HealthDay News) -- U.S. researchers are testing a new approach in cord-blood transplants to treat genetic metabolic disorders in babies while they're still in the womb.

The new method uses a small, select number of therapeutic stem cells that have been treated to speed and improve engraftment (acceptance of the transplant by the body), explained Dr. Joanne Kurtzberg, a professor of pediatrics and pathology and director of the pediatric blood and marrow transplant program at Duke University Medical Center in Durham, N.C.

She and her team are studying the new procedure in a pilot trial open to pregnant women at risk for having children with fatal metabolic disorders, including Krabbe disease, metachromatic leukodystrophy, Pelizaeus-Maerzbacher disease, Tay-Sachs disease and Sandoff disease.

If untreated, these metabolic disorders can lead to bone, brain and central nervous system problems, and early death, the study authors noted in a Duke news release.

Donor cells used in the study will be made by the biopharmaceutical company Aldagen, Inc, which is a partner in the trial.

In many cases, cord-blood transplants after birth have proven successful in treating inherited metabolic disorders. Transplant timing is critical, Kurtzberg stressed.

"The idea is to give the baby cord-blood stem cells from a healthy donor that have the potential to provide healthy genes that can replace the ones that aren't working properly in the baby's own cells," Kurtzberg said in the news release.

In general, the earlier the transplant, the more likely it will work. That means that performing the transplant before the baby is born is ideal, she explained.

During the procedure, donor cells are injected directly into the fetus's abdomen at 12 to 14 weeks' pregnancy. At birth, the baby will be tested to see if the donor cells are present, and if they're fixing the malfunctioning genes. If not, the baby would be eligible for conventional cord-blood stem cell transplant within a few weeks.

More information

The Nemours Foundation has more about metabolism and metabolic disorders.

SOURCE: Duke Medicine, news release, Oct. 13, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com