Transplant for Metabolic Disorders Redding CA

U.S. researchers are testing a new approach in cord-blood transplants to treat genetic metabolic disorders in babies while they're still in the womb. The new method uses a small, select number of therapeutic stem cells that have been treated to speed and improve engraftment (acceptance of the transplant by the body), explained Dr. Joanne Kurtzberg, a professor of pediatrics and pathology and director of the pediatric blood and marrow transplant program at Duke University Medical Center in Durham, N.C.

John Emmons Coe, MD
2480 Sonoma St
Redding, CA
Specialties
Allergy & Immunology
Gender
Male
Education
Medical School: Hahnemann Univ Sch Of Med, Philadelphia Pa 19102
Graduation Year: 1957

Data Provided by:
Ronald Lee Renard, MD
(530) 226-5325
1505 Victor Ave
Redding, CA
Specialties
Allergy & Immunology
Gender
Male
Education
Medical School: Creighton Univ Sch Of Med, Omaha Ne 68178
Graduation Year: 1976

Data Provided by:
Renard Ronald L MD
(530) 226-5325
1505 Victor Ave
Redding, CA

Data Provided by:
Elvia Stavropoulos MD
(323) 721-6103
5373 Whittier Blvd
Los Angeles, CA
Business
Allergy Control Center & Medicine
Specialties
Allergy & Immunology
Insurance
Medicare Accepted: No
Workmens Comp Accepted: No
Accepts Uninsured Patients: No
Emergency Care: No


Data Provided by:
Jorge A Quel, MD
(310) 823-6766
4644 Lincoln Blvd
Marina Del Rey, CA
Business
Allergy Asthma & Sinus Center
Specialties
Allergy & Immunology

Data Provided by:
Eduardo Enrique Chang, MD
(530) 953-9728
180 Northpoint Dr
Redding, CA
Specialties
Allergy & Immunology
Gender
Male
Education
Medical School: Loma Linda Univ Sch Of Med, Loma Linda Ca 92350
Graduation Year: 1995

Data Provided by:
Ronald L Renard
(530) 226-5325
1505 Victor Ave
Redding, CA
Specialty
Allergy / Immunology

Data Provided by:
Robert W Eitches, MD
(310) 657-4600
8631 W 3rd St
Los Angeles, CA
Business
Robert Eitches MD & Maxine Baum MD
Specialties
Allergy & Immunology

Data Provided by:
Kristina H Philpott, MD
(510) 490-1222
3200 Kearney St
Fremont, CA
Business
Palo Alto Medical Foundation Fremont Center
Specialties
Allergy & Immunology

Data Provided by:
Robert Eitches MD
(310) 657-4600
8631 West 3rd Street
Los Angeles, CA
Business
Allergy Foundation Medical Group
Specialties
Allergy & Immunology
Insurance
Medicare Accepted: No
Workmens Comp Accepted: No
Accepts Uninsured Patients: No
Emergency Care: No


Data Provided by:
Data Provided by:

Transplant for Metabolic Disorders

Provided By:

FRIDAY, Oct. 16 (HealthDay News) -- U.S. researchers are testing a new approach in cord-blood transplants to treat genetic metabolic disorders in babies while they're still in the womb.

The new method uses a small, select number of therapeutic stem cells that have been treated to speed and improve engraftment (acceptance of the transplant by the body), explained Dr. Joanne Kurtzberg, a professor of pediatrics and pathology and director of the pediatric blood and marrow transplant program at Duke University Medical Center in Durham, N.C.

She and her team are studying the new procedure in a pilot trial open to pregnant women at risk for having children with fatal metabolic disorders, including Krabbe disease, metachromatic leukodystrophy, Pelizaeus-Maerzbacher disease, Tay-Sachs disease and Sandoff disease.

If untreated, these metabolic disorders can lead to bone, brain and central nervous system problems, and early death, the study authors noted in a Duke news release.

Donor cells used in the study will be made by the biopharmaceutical company Aldagen, Inc, which is a partner in the trial.

In many cases, cord-blood transplants after birth have proven successful in treating inherited metabolic disorders. Transplant timing is critical, Kurtzberg stressed.

"The idea is to give the baby cord-blood stem cells from a healthy donor that have the potential to provide healthy genes that can replace the ones that aren't working properly in the baby's own cells," Kurtzberg said in the news release.

In general, the earlier the transplant, the more likely it will work. That means that performing the transplant before the baby is born is ideal, she explained.

During the procedure, donor cells are injected directly into the fetus's abdomen at 12 to 14 weeks' pregnancy. At birth, the baby will be tested to see if the donor cells are present, and if they're fixing the malfunctioning genes. If not, the baby would be eligible for conventional cord-blood stem cell transplant within a few weeks.

More information

The Nemours Foundation has more about metabolism and metabolic disorders.

SOURCE: Duke Medicine, news release, Oct. 13, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com