Treatment for Alzheimer's Disease Visalia CA

Read more about Vitamin D Plus Curcumin May Prevent and Treat Alzheimer's Disease.

Lawrence F Pearson MD
(559) 627-6165
419 W Murray Ave
Visalia, CA
Specialties
Obstetrics & Gynecology

Data Provided by:
Dr. Randy Bernabe
(559) 589-6294
1560 W. Lacey Blvd.
Hanford, CA
Business
Advanced Orthopedics
Specialties
Orthopedics
Insurance
Insurance Plans Accepted: We accept most PPO's, HMO's, private insurance, Medicare, and Worker Comp insurance.
Medicare Accepted: Yes
Workmens Comp Accepted: Yes
Accepts Uninsured Patients: No
Emergency Care: No

Doctor Information
Primary Hospital: Hanford Community Medical Center
Residency Training: Ohio University at Cuyahoga Falls General Hospital,
Medical School: Des Moines University, College of Osteopathic Medicine and Health Sciences,, 1994
Additional Information
Languages Spoken: English,Spanish,Tagalog

Data Provided by:
Amar Kadakia
(559) 741-4500
400 E Oak Ave
Visalia, CA
Specialty
Internal Medicine

Data Provided by:
Russell Thomas Mitts, MD
(559) 734-6701
515 W Acequia Ave
Visalia, CA
Specialties
Obstetrics & Gynecology, General Practice
Gender
Male
Languages
Spanish
Education
Medical School: Loma Linda Univ Sch Of Med, Loma Linda Ca 92350
Graduation Year: 1947
Hospital
Hospital: Kaweah Delta District Hosp, Visalia, Ca
Group Practice: Mitts & Said

Data Provided by:
William John mark Roach
(559) 738-8584
1860 S Central St
Visalia, CA
Specialty
Family Practice

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Mendonca Chiropractic Group
(559) 759-6996
1699 E Prosperity Ave
Tulare, CA

Data Provided by:
Christopher L Villard, MD
(559) 733-5050
1027 N Demaree St
Visalia, CA
Specialties
Dermatology, General Practice
Gender
Male
Education
Medical School: Univ Of Ca, Los Angeles, Ucla Sch Of Med, Los Angeles Ca 90024
Graduation Year: 1978
Hospital
Hospital: Kaweah Delta District Hosp, Visalia, Ca

Data Provided by:
Robert Allan Havard
(559) 624-3000
4945 W Cypress Ave
Visalia, CA
Specialty
Internal Medicine, Hematology, Medical Oncology

Data Provided by:
James William Foxe
(559) 738-8584
1860 S Central St
Visalia, CA
Specialty
Family Practice

Data Provided by:
Christopher Rodarte
(559) 741-4500
400 E Oak Ave
Visalia, CA
Specialty
Family Practice, Emergency Medicine

Data Provided by:
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Treatment for Alzheimer's Disease

Vitamin D Plus Curcumin May Prevent and Treat Alzheimer's Disease.
Date: Monday, August 03, 2009
Source: Journal of Alzheimer's Disease
Related Monographs: Alzheimer's Disease/Dementia, Turmeric, Vitamin D
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©2000-2009 CCG, Inc. All Rights Reserved.

Alzheimer's is a debilitating disease that causes severe degeneration of brain tissue. Plaque deposits accumulate in the spaces between brain cells. The cells themselves form twisted, spaghetti-like masses called "neurofibrillary tangles." Why these changes happen in the brains of some people but not others remains a matter of speculation. Scientists are unsure as to which of these abnormalities occurs first, the plaque or the tangles. What triggers them in the first place is not known for certain. One leading theory involves a protein called "amyloid" that builds up on the surface of brain cells in Alzheimer's sufferers. An especially sticky form of amyloid protein fills up the plaque deposits observed in Alzheimer's disease. As the amyloid laden plaque deposits grow, they trigger an inflammatory immune reaction that begins to destroy the surrounding brain neurons. Amyloid synthesis is controlled by an enzyme called "secretase." Researchers are now developing a class of drugs called secretase inhibitors that may be able to inhibit excess production of amyloid in people with Alzheimer's disease.

Vitamin D is known as the "sunshine" vitamin because it is formed in the body by the action of the sun's ultraviolet rays on the skin. The fat-soluble vitamin is converted in the kidneys to the hormone calcitrol, which is actually the most active form of vitamin D. The effects of this hormone are targeted at the intestines and bones.

 

The rhizome and root of turmeric has been used for centuries in the Indian medical practice of Ayurveda. Indian practitioners have used turmeric as a tonic for the stomach and liver and as purifier of the blood. Research suggests that turmeric may have unique anti-inflammatory properties. Scientists think the active components in turmeric, called curcuminoids, may inhibit inflammation in a manner similar to that of conventional drugs like ibuprofen, aspirin and more recently the new Cox-2 inhibitors.

 

New research has found that a combination of vitamin D3 and curcumin may boost the immune system and protect the brain from Alzheimer's disease. The study, published in the Journal of Alzheimer's Disease, included nine patients with Alzheimer's disease, one patient with mild cognitive decline and three healthy control subjects. Blood samples were taken from each of the participants and the researchers isolated the monocyte cells, which transform into macrophages and in turn boost the immune system. The macrophages were then incubated with beta-amyloid, vitamin D3 and natural or synthetic curcumin. The researchers found that the naturally occurring curcumin was poorly absorbed, which made it less effective than the synthetic curcuminoids. The results of the study indicate that curcuminoids enhance the binding of beta-amyloid to macrophages, and that vitamin D could strongly stimulate the uptake and absorption of beta-amyloid in macrophages in most of the patients. The researchers concluded that since vitamin D and curcumin appear to work differently in the immune system, it may be found that either a combination of the two or possibly each used separately may prove most effective, but that currently, they cannot recommend any specific dosage for either compound since further research is necessary.1

 

1 Masoumi A, Goldenson B, Ghirmai S, et al. 1alpha,25-dihydroxyvitamin D<formula>_{3}</formula> Interacts with Curcuminoids to Stimulate Amyloid-beta Clearance by Macrophages of Alzheimer's Disease Patients. J Alzheimers Dis. 2009;17(3):703-717.

This information is educational in context and is not to be used to diagnose, treat or cure any disease. Please consult your licensed health care practitioner before using this or any medical information.
©2000-2009 CCG, Inc. All Rights Reserved.